Endocrine System — Checklist 內分泌系統 (nèifēnmì xìtǒng)
Organisation: Functional first, anatomical second. Reference: See
endocrine-system-reference.mdfor functional descriptions, hormone mechanisms, and clinical notes.
1. Hypothalamus — 下丘腦 (xiàqiūnǎo)
1.1 Releasing / Inhibiting Hormones — 釋放/抑制激素 (shìfàng / yìzhì jīsù)
- TRH (Thyrotropin-Releasing Hormone) — 促甲狀腺激素釋放激素 (cù jiǎzhuàngxiàn jīsù shìfàng jīsù)
- CRH (Corticotropin-Releasing Hormone) — 促腎上腺皮質激素釋放激素 (cù shènshàngxiàn pízhì jīsù shìfàng jīsù)
- GnRH (Gonadotropin-Releasing Hormone) — 促性腺激素釋放激素 (cù xìngxiàn jīsù shìfàng jīsù)
- GHRH (Growth Hormone-Releasing Hormone) — 生長激素釋放激素 (shēngzhǎng jīsù shìfàng jīsù)
- Somatostatin (GHIH) — 生長抑素 (shēngzhǎng yìsù)
- Dopamine (Prolactin-Inhibiting Factor) — 多巴胺(泌乳素抑制因子)(duōbā’àn (mìrǔsù yìzhì yīnzǐ))
1.2 Neurohypophyseal Hormones — 神經垂體激素 (shénjīng chuítǐ jīsù)
- ADH / Vasopressin (AVP) — 抗利尿激素/血管加壓素 (kàng lìniào jīsù / xuèguǎn jiāyāsù)
- Oxytocin — 催產素 (cuīchǎnsù)
1.3 Key Hypothalamic Nuclei — 主要下丘腦核團 (zhǔyào xiàqiūnǎo hétuán)
- Supraoptic nucleus (SON) — 視上核 (shìshànghé)
- Paraventricular nucleus (PVN) — 室旁核 (shìpánghé)
- Arcuate nucleus (ARC) — 弓狀核 (gōngzhuànghé)
- Ventromedial nucleus (VMN) — 腹內側核 (fùnèicèhé)
- Lateral hypothalamic area — 下丘腦外側區 (xiàqiūnǎo wàicèqū)
- Suprachiasmatic nucleus (SCN) — 視交叉上核 (shìjiāochā shànghé)
- Preoptic area — 視前區 (shìqiánqū)
- Dorsomedial nucleus (DMN) — 背內側核 (bèinèicèhé)
- Periventricular nucleus — 室周核 (shìzhōuhé)
1.4 Hypothalamic-Hypophyseal Portal System — 下丘腦-垂體門脈系統 (xiàqiūnǎo-chuítǐ ménmài xìtǒng)
- Superior hypophyseal arteries — 垂體上動脈 (chuítǐ shàng dòngmài)
- Primary capillary plexus (median eminence) — 初級毛細血管叢(正中隆起)(chūjí máoxì xuèguǎn cóng (zhèngzhōng lóngqǐ))
- Hypophyseal portal veins (long portal vessels) — 垂體門靜脈(長門脈)(chuítǐ mén jìngmài (cháng ménmài))
- Secondary capillary plexus (anterior pituitary) — 次級毛細血管叢(腺垂體)(cìjí máoxì xuèguǎn cóng (xiàn chuítǐ))
- Short portal vessels — 短門脈 (duǎn ménmài)
2. Pituitary Gland — 垂體 (chuítǐ)
2.1 Anterior Pituitary (Adenohypophysis) — 腺垂體 (xiàn chuítǐ)
- Pars Distalis — 遠側部 (yuǎncèbù)
- Somatotrophs → GH — 生長激素細胞→生長激素 (shēngzhǎng jīsù xìbāo → shēngzhǎng jīsù)
- Lactotrophs → Prolactin — 泌乳素細胞→泌乳素 (mìrǔsù xìbāo → mìrǔsù)
- Corticotrophs → ACTH, β-LPH, β-Endorphin, MSH (from POMC) — 促腎上腺皮質激素細胞→促腎上腺皮質激素、β-脂促素、β-內啡肽、促黑素(來自POMC)(cù shènshàngxiàn pízhì jīsù xìbāo → cù shènshàngxiàn pízhì jīsù, β-zhīcùsù, β-nèifēitài, cùhēisù (láizì POMC))
- Thyrotrophs → TSH — 促甲狀腺激素細胞→促甲狀腺激素 (cù jiǎzhuàngxiàn jīsù xìbāo → cù jiǎzhuàngxiàn jīsù)
- Gonadotrophs → FSH, LH — 促性腺激素細胞→卵泡刺激素、黃體生成素 (cù xìngxiàn jīsù xìbāo → luǎnpào cìjīsù, huángtǐ shēngchéngsù)
- Folliculostellate cells (paracrine) — 濾泡星形細胞(旁分泌)(lǜpào xīngxíng xìbāo (páng fēnmì))
- Pars Tuberalis — 結節部 (jiéjiébù)
- Gonadotrophs, thyrotrophs — 促性腺激素細胞、促甲狀腺激素細胞 (cù xìngxiàn jīsù xìbāo, cù jiǎzhuàngxiàn jīsù xìbāo)
- Melatonin receptors (MT1) — 褪黑素受體 (tuìhēisù shòutǐ)
- Pars Intermedia — 中間部 (zhōngjiānbù)
- Melanotrophs → MSH — 促黑素細胞→促黑素 (cùhēisù xìbāo → cùhēisù)
- Rathke’s cleft remnants — 拉特克囊殘餘 (lātèkè náng cányú)
2.2 Posterior Pituitary (Neurohypophysis) — 神經垂體 (shénjīng chuítǐ)
- Pars Nervosa — 神經部 (shénjīngbù)
- Herring bodies — 赫林體 (hèlíntǐ)
- Pituicytes — 垂體細胞 (chuítǐ xìbāo)
- Oxytocin release — 催產素釋放 (cuīchǎnsù shìfàng)
- ADH/Vasopressin release — 抗利尿激素釋放 (kàng lìniào jīsù shìfàng)
- Infundibulum — 漏斗 (lòudǒu)
- Hypothalamo-hypophyseal tract — 下丘腦-垂體束 (xiàqiūnǎo-chuítǐ shù)
- Portal vessels — 門脈 (ménmài)
3. Pineal Gland — 松果體 (sōngguǒtǐ)
3.1 Structure — 結構 (jiégòu)
- Pinealocytes — 松果體細胞 (sōngguǒtǐ xìbāo)
- Interstitial (glial) cells — 間質(膠質)細胞 (jiānzhì (jiāozhì) xìbāo)
- Perivascular phagocytes — 血管周圍吞噬細胞 (xuèguǎn zhōuwéi tūnshì xìbāo)
- Corpora arenacea (brain sand) — 腦砂 (nǎoshā)
3.2 Hormones — 激素 (jīsù)
- Melatonin — 褪黑素 (tuìhēisù)
- Dimethyltryptamine (DMT) — 二甲基色胺(微量)(èrjiǎjī sè’àn (wēiliàng))
- Serotonin (precursor) — 血清素(前驅物)(xuèqīngsù (qiánqūwù))
4. Thyroid Gland — 甲狀腺 (jiǎzhuàngxiàn)
4.1 Gross Anatomy — 大體解剖 (dàtǐ jiěpōu)
- Right lobe — 右葉 (yòuyè)
- Left lobe — 左葉 (zuǒyè)
- Isthmus — 峽部 (xiábù)
- Pyramidal lobe (~50%) — 錐體葉(約50%)(zhuītǐyè (yuē 50%))
- Capsule (true and false) — 被膜(真被膜與假被膜)(bèimó (zhēn bèimó yǔ jiǎ bèimó))
- Ligament of Berry — 貝里韌帶 (bèilǐ rèndài)
4.2 Follicular Cells (Thyrocytes) — 濾泡細胞 (lǜpào xìbāo)
- Thyroglobulin — 甲狀腺球蛋白 (jiǎzhuàngxiàn qiú dànbái)
- NIS (sodium-iodide symporter) — 鈉碘共轉運體 (nà diǎn gòng zhuǎnyùntǐ)
- Thyroid peroxidase (TPO) — 甲狀腺過氧化物酶 (jiǎzhuàngxiàn guòyǎnghuàwù méi)
- T4 (Thyroxine) — 甲狀腺素(四碘甲腺原氨酸)(jiǎzhuàngxiànsù (sì diǎn jiǎxiàn yuán ānjīsuān))
- T3 (Triiodothyronine) — 三碘甲腺原氨酸 (sān diǎn jiǎxiàn yuán ānjīsuān)
- rT3 (Reverse T3) — 反向三碘甲腺原氨酸 (fǎnxiàng sān diǎn jiǎxiàn yuán ānjīsuān)
- Colloid — 膠質 (jiāozhì)
- Pendrin — 碘轉運蛋白 (diǎn zhuǎnyùn dànbái)
- Deiodinases (D1, D2, D3) — 脫碘酶 (tuōdiǎn méi)
4.3 Parafollicular Cells (C-cells) — 濾泡旁細胞(C細胞)(lǜpào páng xìbāo (C xìbāo))
- Calcitonin — 降鈣素 (jiànggàisù)
4.4 Thyroid Vasculature — 甲狀腺血管 (jiǎzhuàngxiàn xuèguǎn)
- Superior thyroid artery — 甲狀腺上動脈 (jiǎzhuàngxiàn shàng dòngmài)
- Inferior thyroid artery — 甲狀腺下動脈 (jiǎzhuàngxiàn xià dòngmài)
- Thyroid ima artery (inconstant) — 甲狀腺最下動脈(不恆定)(jiǎzhuàngxiàn zuìxià dòngmài (bù héngdìng))
- Superior/middle/inferior thyroid veins — 甲狀腺上/中/下靜脈 (jiǎzhuàngxiàn shàng / zhōng / xià jìngmài)
4.5 Associated Structures — 相關結構 (xiāngguān jiégòu)
- Recurrent laryngeal nerves — 喉返神經 (hóufǎn shénjīng)
- External branch of superior laryngeal nerve — 喉上神經外支 (hóushàng shénjīng wàizhī)
5. Parathyroid Glands — 副甲狀腺 (fùjiǎzhuàngxiàn)
5.1 Anatomy — 解剖 (jiěpōu)
- Superior parathyroids (paired) — 上副甲狀腺(成對)(shàng fùjiǎzhuàngxiàn (chéngduì))
- Inferior parathyroids (paired) — 下副甲狀腺(成對)(xià fùjiǎzhuàngxiàn (chéngduì))
- Supernumerary glands (5-13%) — 額外腺體(5-13%)(éwài xiàntǐ (5-13%))
- Ectopic locations — 異位位置 (yìwèi wèizhì)
5.2 Chief Cells — 主細胞 (zhǔ xìbāo)
- PTH (Parathyroid Hormone) — 副甲狀腺素 (fùjiǎzhuàngxiànsù)
- Calcium-sensing receptor (CaSR) — 鈣敏感受體 (gài mǐngǎn shòutǐ)
5.3 Oxyphil Cells — 嗜酸性細胞 (shìsuānxìng xìbāo)
6. Adrenals & Gonads — 腎上腺與性腺 (shènshàngxiàn yǔ xìngxiàn)
6.1 Shared Steroidogenesis Pathway — 共同類固醇合成途徑 (gòngtóng lèigùchún héchéng tújìng)
6.1.1 Rate-Limiting Entry Step — 限速起始步驟 (xiànsù qǐshǐ bùzhòu)
- Cholesterol → Pregnenolone (StAR + CYP11A1) — 膽固醇→孕烯醇酮(StAR蛋白+膽固醇側鏈裂解酶)(dǎngùchún → yùnxī’chúntóng (StAR dànbái + dǎngùchún cèliàn lièjiě méi))
6.1.2 Branch Enzymes — 分支酶 (fēnzhī méi)
- CYP17 (17α-hydroxylase / 17,20-lyase) — 17α-羥化酶/17,20-裂解酶 (17α-qiǎnghuà méi / 17,20-lièjiě méi)
- CYP21 (21-hydroxylase) — 21-羥化酶 (21-qiǎnghuà méi)
- CYP11B1 (11β-hydroxylase) — 11β-羥化酶 (11β-qiǎnghuà méi)
- CYP11B2 (aldosterone synthase) — 醛固酮合成酶 (quángùtóng héchéng méi)
- CYP19 (aromatase) — 芳香化酶 (fāngxiānghuà méi)
- 3β-HSD — 3β-羥基類固醇脫氫酶 (3β-qiǎngjī lèigùchún tuōqīng méi)
- 17β-HSD — 17β-羥基類固醇脫氫酶 (17β-qiǎngjī lèigùchún tuōqīng méi)
6.1.3 Pathway Branches — 途徑分支 (tújìng fēnzhī)
- Mineralocorticoid: Pregnenolone → Progesterone → DOC → Corticosterone → Aldosterone — 鹽皮質激素:孕烯醇酮→黃體酮→去氧皮質酮→皮質酮→醛固酮 (yán pízhì jīsù: yùnxī’chúntóng → huángtǐtóng → qùyǎng pízhìtóng → pízhìtóng → quángùtóng)
- Glucocorticoid: Pregnenolone → 17-OH-Pregnenolone → 17-OH-Progesterone → 11-Deoxycortisol → Cortisol — 糖皮質激素:孕烯醇酮→17-羥孕烯醇酮→17-羥黃體酮→11-去氧皮質醇→皮質醇 (táng pízhì jīsù: yùnxī’chúntóng → 17-qiǎng yùnxī’chúntóng → 17-qiǎng huángtǐtóng → 11-qùyǎng pízhìchún → pízhìchún)
- Androgen: Pregnenolone → 17-OH-Pregnenolone → DHEA → Androstenedione → Testosterone — 雄激素:孕烯醇酮→17-羥孕烯醇酮→去氫表雄酮→雄烯二酮→睪酮 (xióng jīsù: yùnxī’chúntóng → 17-qiǎng yùnxī’chúntóng → qùqīng biǎoxióngtóng → xióngxī’èrtóng → gāotóng)
- Oestrogen: Testosterone → Oestradiol (aromatase) — 雌激素:睪酮→雌二醇(芳香化酶)(cí jīsù: gāotóng → cí’èrchún (fāngxiānghuà méi))
- DHT: Testosterone → Dihydrotestosterone (5α-reductase) — 二氫睪酮:睪酮→二氫睪酮(5α-還原酶)(èrqīng gāotóng: gāotóng → èrqīng gāotóng (5α-huányuán méi))
6.2 Adrenal Cortex — 腎上腺皮質 (shènshàngxiàn pízhì)
6.2.1 Zona Glomerulosa — 球狀帶 (qiúzhuàngdài)
- Aldosterone — 醛固酮 (quángùtóng)
- Deoxycorticosterone (DOC) — 去氧皮質酮 (qùyǎng pízhìtóng)
6.2.2 Zona Fasciculata — 束狀帶 (shùzhuàngdài)
- Cortisol — 皮質醇 (pízhìchún)
- Corticosterone — 皮質酮 (pízhìtóng)
- Cortisone — 可的松 (kědìsōng)
6.2.3 Zona Reticularis — 網狀帶 (wǎngzhuàngdài)
- DHEA — 去氫表雄酮 (qùqīng biǎoxióngtóng)
- DHEA-S — 硫酸去氫表雄酮 (liúsuān qùqīng biǎoxióngtóng)
- Androstenedione — 雄烯二酮 (xióngxī’èrtóng)
- Testosterone (small amounts) — 睪酮(少量)(gāotóng (shǎoliàng))
- Oestrogen (small amounts) — 雌激素(少量)(cí jīsù (shǎoliàng))
6.3 Gonadal Endocrine Function — 性腺內分泌功能 (xìngxiàn nèifēnmì gōngnéng)
6.3.1 Testicular Endocrine Cells — 睪丸內分泌細胞 (gāowán nèifēnmì xìbāo)
- Leydig cells — 萊氏細胞(間質細胞)(láishì xìbāo (jiānzhì xìbāo))
- Testosterone — 睪酮 (gāotóng)
- INSL3 — 胰島素樣因子3 (yídǎosù yàng yīnzǐ 3)
- Sertoli cells — 塞爾托利細胞(支持細胞)(sài’ěrtuōlì xìbāo (zhīchí xìbāo))
- Inhibin B — 抑制素B (yìzhìsù B)
- Activin — 活化素 (huóhuàsù)
- AMH — 抗苗勒管激素 (kàng miáolēiguǎn jīsù)
- Androgen-Binding Protein (ABP) — 雄激素結合蛋白 (xióng jīsù jiéhé dànbái)
- Oestradiol (local) — 雌二醇(局部)(cí’èrchún (júbù))
- Blood-testis barrier — 血睪屏障 (xuègāo píngzhàng)
6.3.2 Ovarian Endocrine Cells — 卵巢內分泌細胞 (luǎncháo nèifēnmì xìbāo)
- Theca interna cells — 卵泡膜內層細胞 (luǎnpàomó nèicéng xìbāo)
- Androstenedione, Testosterone — 雄烯二酮、睪酮 (xióngxī’èrtóng, gāotóng)
- Granulosa cells — 顆粒細胞 (kēlì xìbāo)
- Oestradiol (E2) — 雌二醇 (cí’èrchún)
- Inhibin A & B — 抑制素A與B (yìzhìsù A yǔ B)
- AMH — 抗苗勒管激素 (kàng miáolēiguǎn jīsù)
- Corpus luteum — 黃體 (huángtǐ)
- Progesterone — 黃體酮(孕酮)(huángtǐtóng (yùntóng))
- Oestradiol — 雌二醇 (cí’èrchún)
- Inhibin A — 抑制素A (yìzhìsù A)
- Relaxin — 鬆弛素 (sōngchísù)
- Granulosa-lutein cells — 顆粒黃體細胞 (kēlì huángtǐ xìbāo)
- Theca-lutein cells — 卵泡膜黃體細胞 (luǎnpàomó huángtǐ xìbāo)
- Ovarian stroma — 卵巢基質 (luǎncháo jīzhì)
- Interstitial cells — 間質細胞 (jiānzhì xìbāo)
- Hilar cells — 門細胞 (mén xìbāo)
6.3.3 Placental Endocrine Function — 胎盤內分泌功能 (tāipán nèifēnmì gōngnéng)
- hCG — 人絨毛膜促性腺激素 (rén róngmáomó cù xìngxiàn jīsù)
- hPL (Human Placental Lactogen) — 人胎盤催乳素 (rén tāipán cuīrǔsù)
- Progesterone — 黃體酮 (huángtǐtóng)
- Oestrogens (E3 predominant) — 雌激素(雌三醇為主)(cí jīsù (císānchún wéi zhǔ))
- CRH (Placental) — 胎盤促腎上腺皮質激素釋放激素 (tāipán cù shènshàngxiàn pízhì jīsù shìfàng jīsù)
- Placental GH (GH-V) — 胎盤生長激素 (tāipán shēngzhǎng jīsù)
- Inhibin A — 抑制素A (yìzhìsù A)
- Kisspeptin — 親吻肽 (qīnwěntài)
- PAPP-A — 妊娠相關血漿蛋白A (rènshēn xiāngguān xuèjiāng dànbái A)
6.4 Adrenal Medulla & Paraganglia — 腎上腺髓質與副神經節 (shènshàngxiàn suǐzhì yǔ fùshénjīngjié)
6.4.1 Adrenal Medulla — 腎上腺髓質 (shènshàngxiàn suǐzhì)
- Chromaffin cells — 嗜鉻細胞 (shìgè xìbāo)
- Adrenaline (Epinephrine) — 腎上腺素(~80%)(shènshàngxiànsù (~80%))
- Noradrenaline (Norepinephrine) — 去甲腎上腺素(~20%)(qùjiǎ shènshàngxiànsù (~20%))
- PNMT — 苯乙醇胺N-甲基轉移酶 (běnyǐchún’àn N-jiǎjī zhuǎnyí méi)
- Catecholamine pathway — 兒茶酚胺合成途徑 (ércháfēn’àn héchéng tújìng)
- Tyrosine → DOPA → Dopamine → Noradrenaline → Adrenaline — 酪氨酸→多巴→多巴胺→去甲腎上腺素→腎上腺素 (lào’ānjīsuān → duōbā → duōbā’àn → qùjiǎ shènshàngxiànsù → shènshàngxiànsù)
- Other products — 其他產物 (qítā chǎnwù)
- Dopamine — 多巴胺 (duōbā’àn)
- Enkephalins (Met-, Leu-) — 腦啡肽(甲硫、亮)(nǎofēitài (jiǎliú, liàng))
- Chromogranins (A, B) — 嗜鉻粒蛋白 (shìgè lì dànbái)
- Neuropeptide Y — 神經肽Y (shénjīngtài Y)
- Sustentacular cells — 支持細胞 (zhīchí xìbāo)
- Ganglion cells — 神經節細胞 (shénjīngjié xìbāo)
6.4.2 Extra-Adrenal Paraganglia — 腎上腺外副神經節 (shènshàngxiàn wài fùshénjīngjié)
- Sympathetic — 交感型 (jiāogǎnxíng)
- Organ of Zuckerkandl — 祖克坎德爾器官 (zǔkèkǎndé’ěr qìguān)
- Bladder wall paraganglia — 膀胱壁副神經節 (pángguāngbì fùshénjīngjié)
- Retroperitoneal paraganglia — 腹膜後副神經節 (fùmóhòu fùshénjīngjié)
- Parasympathetic — 副交感型 (fùjiāogǎnxíng)
- Carotid body (Type I glomus, Type II sustentacular) — 頸動脈體(I型球細胞、II型支持細胞)(jǐngdòngmàitǐ (I xíng qiú xìbāo, II xíng zhīchí xìbāo))
- Aortic bodies — 主動脈體 (zhǔdòngmàitǐ)
- Jugulotympanic paraganglia — 頸靜脈鼓室副神經節 (jǐngjìngmài gǔshì fùshénjīngjié)
- Vagal paraganglia — 迷走神經副神經節 (mízǒu shénjīng fùshénjīngjié)
6.5 Adrenal Vasculature — 腎上腺血管 (shènshàngxiàn xuèguǎn)
- Superior adrenal arteries (from inferior phrenic) — 腎上腺上動脈(來自膈下動脈)(shènshàngxiàn shàng dòngmài (láizì géxià dòngmài))
- Middle adrenal arteries (from aorta) — 腎上腺中動脈(來自主動脈)(shènshàngxiàn zhōng dòngmài (láizì zhǔdòngmài))
- Inferior adrenal arteries (from renal) — 腎上腺下動脈(來自腎動脈)(shènshàngxiàn xià dòngmài (láizì shèn dòngmài))
- Cortical sinusoids (centripetal flow) — 皮質竇(向心血流)(pízhì dòu (xiàngxīn xuèliú))
- Adrenal veins (right → IVC; left → renal vein) — 腎上腺靜脈(右→下腔靜脈;左→腎靜脈)(shènshàngxiàn jìngmài (yòu → xiàqiāng jìngmài; zuǒ → shèn jìngmài))
7. Pancreatic Islets — 胰島 (yídǎo)
7.1 Islet Cell Types — 胰島細胞類型 (yídǎo xìbāo lèixíng)
7.1.1 Beta Cells (β) — β細胞(60-80%)(β xìbāo (60-80%))
- Insulin — 胰島素 (yídǎosù)
- Amylin (IAPP) — 胰淀粉樣多肽 (yí diànfěnyàng duōtài)
- C-peptide — C肽 (C tài)
7.1.2 Alpha Cells (α) — α細胞(15-20%)(α xìbāo (15-20%))
- Glucagon — 胰高血糖素 (yí gāo xuètángsù)
7.1.3 Delta Cells (δ) — δ細胞(5-10%)(δ xìbāo (5-10%))
- Somatostatin — 生長抑素 (shēngzhǎng yìsù)
7.1.4 PP Cells (F) — PP細胞(1-2%)(PP xìbāo (1-2%))
- Pancreatic Polypeptide — 胰多肽 (yí duōtài)
7.1.5 Epsilon Cells (ε) — ε細胞(<1%)(ε xìbāo (<1%))
- Ghrelin — 飢餓素 (jī’èsù)
7.2 Islet Architecture — 胰島結構 (yídǎo jiégòu)
- Core: β-cells (central) — 核心:β細胞(中央)(héxīn: β xìbāo (zhōngyāng))
- Mantle: α-cells, δ-cells (peripheral) — 外套:α細胞、δ細胞(周邊)(wàitào: α xìbāo, δ xìbāo (zhōubiān))
- Dense capillary network — 密集毛細血管網 (mìjí máoxì xuèguǎn wǎng)
- Autonomic innervation — 自主神經支配 (zìzhǔ shénjīng zhīpèi)
- ~1-2 million islets per pancreas — 每胰臟約1-2百萬個胰島 (měi yízàng yuē 1-2 bǎiwàn gè yídǎo)
- Islet-acinar portal system — 胰島-腺泡門脈系統 (yídǎo-xiànpào ménmài xìtǒng)
7.3 Pancreas Anatomy — 胰臟解剖 (yízàng jiěpōu)
- Head (uncinate process) — 頭部(鈎突)(tóubù (gōutū))
- Neck — 頸部 (jǐngbù)
- Body — 體部 (tǐbù)
- Tail (highest islet density) — 尾部(胰島密度最高)(wěibù (yídǎo mìdù zuìgāo))
- Main pancreatic duct (Wirsung) — 主胰管(維爾松管)(zhǔ yíguǎn (wéi’ěrsōng guǎn))
- Accessory duct (Santorini) — 副胰管(桑托里尼管)(fù yíguǎn (sāngtuōlǐní guǎn))
8. Diffuse Neuroendocrine System (DNES) — 瀰漫性神經內分泌系統 (mímànxìng shénjīng nèifēnmì xìtǒng)
8.1 Gastrointestinal Enteroendocrine Cells — 胃腸道腸內分泌細胞 (wèichángdào cháng nèifēnmì xìbāo)
8.1.1 Stomach — 胃 (wèi)
- G-cells → Gastrin — G細胞→胃泌素 (G xìbāo → wèimìsù)
- ECL cells → Histamine — 腸嗜鉻樣細胞→組胺 (cháng shìgè yàng xìbāo → zǔ’àn)
- D-cells → Somatostatin — D細胞→生長抑素 (D xìbāo → shēngzhǎng yìsù)
- P/D1 cells → Ghrelin — P/D1細胞→飢餓素 (P/D1 xìbāo → jī’èsù)
- EC cells → Serotonin (5-HT) — 腸嗜鉻細胞→血清素 (cháng shìgè xìbāo → xuèqīngsù)
8.1.2 Small Intestine — 小腸 (xiǎocháng)
- I-cells → CCK — I細胞→膽囊收縮素 (I xìbāo → dǎnnáng shōusuōsù)
- S-cells → Secretin — S細胞→促胰液素 (S xìbāo → cù yíyèsù)
- K-cells → GIP — K細胞→葡萄糖依賴性促胰島素多肽 (K xìbāo → pútáotáng yīlàixìng cù yídǎosù duōtài)
- L-cells → GLP-1, GLP-2, PYY — L細胞→胰高血糖素樣肽-1、胰高血糖素樣肽-2、肽YY (L xìbāo → yí gāo xuètángsù yàng tài-1, yí gāo xuètángsù yàng tài-2, tài YY)
- M-cells → Motilin — M細胞→胃動素 (M xìbāo → wèidòngsù)
- EC cells → Serotonin — 腸嗜鉻細胞→血清素 (cháng shìgè xìbāo → xuèqīngsù)
- N-cells → Neurotensin — N細胞→神經降壓素 (N xìbāo → shénjīng jiàngyāsù)
8.1.3 Large Intestine — 大腸 (dàcháng)
- L-cells → GLP-1, PYY — L細胞→胰高血糖素樣肽-1、肽YY (L xìbāo → yí gāo xuètángsù yàng tài-1, tài YY)
- EC cells → Serotonin — 腸嗜鉻細胞→血清素 (cháng shìgè xìbāo → xuèqīngsù)
- D-cells → Somatostatin — D細胞→生長抑素 (D xìbāo → shēngzhǎng yìsù)
8.2 Pulmonary Neuroendocrine Cells — 肺神經內分泌細胞 (fèi shénjīng nèifēnmì xìbāo)
- PNECs → Serotonin, Bombesin/GRP, CGRP — 肺神經內分泌細胞→血清素、蛙皮素/胃泌素釋放肽、降鈣素基因相關肽 (fèi shénjīng nèifēnmì xìbāo → xuèqīngsù, wāpísù / wèimìsù shìfàng tài, jiànggàisù jīyīn xiāngguān tài)
- Neuroepithelial bodies (NEBs) — 神經上皮體 (shénjīng shàngpítǐ)
8.3 Cardiac Endocrine Cells — 心臟內分泌細胞 (xīnzàng nèifēnmì xìbāo)
- Atrial cardiomyocytes → ANP — 心房肌細胞→心房利鈉肽 (xīnfáng jī xìbāo → xīnfáng lìnà tài)
- Ventricular cardiomyocytes → BNP — 心室肌細胞→B型利鈉肽 (xīnshì jī xìbāo → B xíng lìnà tài)
- Vascular endothelium → CNP — 血管內皮→C型利鈉肽 (xuèguǎn nèipí → C xíng lìnà tài)
8.4 Renal Endocrine Function — 腎臟內分泌功能 (shènzàng nèifēnmì gōngnéng)
- Juxtaglomerular cells → Renin — 近腎小球細胞→腎素 (jìn shènxiǎoqiú xìbāo → shènsù)
- Peritubular interstitial cells → EPO — 腎小管周圍間質細胞→紅血球生成素 (shènxiǎoguǎn zhōuwéi jiānzhì xìbāo → hóngxuèqiú shēngchéngsù)
- Proximal tubule → Calcitriol (1,25-dihydroxyvitamin D3) — 近端腎小管→骨化三醇(活性維生素D3)(jìnduān shènxiǎoguǎn → gǔhuà sānchún (huóxìng wéishēngsù D3))
- Macula densa (tubuloglomerular feedback) — 緻密斑(管球反饋)(zhìmìbān (guǎnqiú fǎnkuì))
- Mesangial cells — 腎小球繫膜細胞 (shènxiǎoqiú xìmó xìbāo)
8.5 Hepatic Endocrine Function — 肝臟內分泌功能 (gānzàng nèifēnmì gōngnéng)
- Hepatocytes → IGF-1 — 肝細胞→胰島素樣生長因子-1 (gān xìbāo → yídǎosù yàng shēngzhǎng yīnzǐ-1)
- Hepatocytes → IGF-2 — 肝細胞→胰島素樣生長因子-2 (gān xìbāo → yídǎosù yàng shēngzhǎng yīnzǐ-2)
- Hepatocytes → IGFBP-1 to IGFBP-6 — 肝細胞→胰島素樣生長因子結合蛋白1-6 (gān xìbāo → yídǎosù yàng shēngzhǎng yīnzǐ jiéhé dànbái 1-6)
- Hepatocytes → Hepcidin — 肝細胞→鐵調素 (gān xìbāo → tiědiàosù)
- Hepatocytes → Angiotensinogen — 肝細胞→血管緊張素原 (gān xìbāo → xuèguǎn jǐnzhāngsù yuán)
- Hepatocytes → Thrombopoietin (TPO) — 肝細胞→血小板生成素 (gān xìbāo → xuèxiǎobǎn shēngchéngsù)
- Hepatocytes → FGF21 — 肝細胞→纖維母細胞生長因子21 (gān xìbāo → xiānwéi mǔxìbāo shēngzhǎng yīnzǐ 21)
- Kupffer cells → Cytokines — 庫普弗細胞→細胞因子 (kùpǔfú xìbāo → xìbāo yīnzǐ)
9. Endocrine Tissues — 內分泌組織 (nèifēnmì zǔzhī)
9.1 Adipose Tissue — 脂肪組織 (zhīfáng zǔzhī)
9.1.1 White Adipose Tissue (WAT) — 白色脂肪組織 (báisè zhīfáng zǔzhī)
- Leptin — 瘦素 (shòusù)
- Adiponectin — 脂聯素 (zhīliánsù)
- Resistin — 抵抗素 (dǐkàngsù)
- Visfatin (NAMPT) — 內臟脂肪素 (nèizàng zhīfángsù)
- Apelin — 脂肪因子肽 (zhīfáng yīnzǐ tài)
- Omentin — 網膜素 (wǎngmósù)
- RBP4 — 視黃醇結合蛋白4 (shìhuángchún jiéhé dànbái 4)
- PAI-1 — 纖溶酶原激活物抑制劑-1 (xiānróng méiyuán jīhuówù yìzhìjì-1)
- TNF-α, IL-6 — 腫瘤壞死因子α、白介素-6 (zhǒngliú huàisǐ yīnzǐ α, báijièsù-6)
- Angiotensinogen — 血管緊張素原 (xuèguǎn jǐnzhāngsù yuán)
- Oestrogens (aromatase) — 雌激素(芳香化酶)(cí jīsù (fāngxiānghuà méi))
9.1.2 Brown Adipose Tissue (BAT) — 棕色脂肪組織 (zōngsè zhīfáng zǔzhī)
- FGF21 — 纖維母細胞生長因子21 (xiānwéi mǔxìbāo shēngzhǎng yīnzǐ 21)
- Neuregulin 4 (NRG4) — 神經調節蛋白4 (shénjīng tiáojié dànbái 4)
- 12,13-diHOME — 12,13-二羥基-9Z-十八碳烯酸 (12,13-èr qiǎngjī-9Z-shíbātàn xīsuān)
- UCP1 — 解偶聯蛋白1 (jiě ǒulián dànbái 1)
- BMP8b — 骨形態發生蛋白8b (gǔ xíngtài fāshēng dànbái 8b)
9.1.3 Beige/Brite Adipocytes — 米色脂肪細胞 (mǐsè zhīfáng xìbāo)
- Inducible UCP1 expression — 可誘導的解偶聯蛋白1表達 (kě yòudǎo de jiě ǒulián dànbái 1 biǎodá)
9.2 Bone — Osteokines — 骨骼——骨因子 (gǔgé — gǔ yīnzǐ)
- Osteocalcin (osteoblasts) — 骨鈣素(成骨細胞)(gǔgàisù (chénggǔ xìbāo))
- FGF23 (osteocytes) — 纖維母細胞生長因子23(骨細胞)(xiānwéi mǔxìbāo shēngzhǎng yīnzǐ 23 (gǔ xìbāo))
- Sclerostin (osteocytes) — 硬化蛋白(骨細胞)(yìnghuà dànbái (gǔ xìbāo))
- RANKL (osteoblasts/osteocytes) — 核因子κB受體活化因子配體 (hé yīnzǐ κB shòutǐ huóhuà yīnzǐ pèitǐ)
- OPG (Osteoprotegerin) — 骨保護素 (gǔ bǎohùsù)
9.3 Skeletal Muscle — Myokines — 骨骼肌——肌因子 (gǔgéjī — jī yīnzǐ)
- IL-6 — 白介素-6 (báijièsù-6)
- Irisin (FNDC5) — 鳶尾素 (yuānwěisù)
- Myostatin (GDF-8) — 肌肉生長抑制素 (jīròu shēngzhǎng yìzhìsù)
- IL-15 — 白介素-15 (báijièsù-15)
- BDNF — 腦源性神經營養因子 (nǎoyuánxìng shénjīng yíngyǎng yīnzǐ)
- Meteorin-like (METRNL) — 類流星蛋白 (lèi liúxīng dànbái)
- BAIBA — β-氨基異丁酸 (β-ānjī yìdīngsuān)
9.4 Skin — 皮膚 (pífū)
- Vitamin D3 (Cholecalciferol) — 維生素D3(膽鈣化醇)(wéishēngsù D3 (dǎngàihuà chún))
- Cathelicidin (LL-37) — 抗菌肽LL-37 (kàngjūntài LL-37)
- Dermcidin — 皮膚抗菌肽 (pífū kàngjūntài)
9.5 Thymus (Endocrine Function) — 胸腺(內分泌功能)(xiōngxiàn (nèifēnmì gōngnéng))
9.5.1 Thymic Hormones — 胸腺激素 (xiōngxiàn jīsù)
- Thymosin α1 — 胸腺素α1 (xiōngxiànsù α1)
- Thymosin β4 — 胸腺素β4 (xiōngxiànsù β4)
- Thymulin (FTS) — 胸腺肽(血清胸腺因子)(xiōngxiàntài (xuèqīng xiōngxiàn yīnzǐ))
- Thymopoietin (TP) — 胸腺生成素 (xiōngxiàn shēngchéngsù)
- TSLP — 胸腺基質淋巴細胞生成素 (xiōngxiàn jīzhì línbā xìbāo shēngchéngsù)
9.5.2 Thymic Involution — 胸腺退化 (xiōngxiàn tuìhuà)
- Progressive adipose replacement — 漸進脂肪替代 (jiànjìn zhīfáng tìdài)
- Sex steroid-accelerated — 性激素加速 (xìng jīsù jiāsù)
- Residual function persists — 殘留功能持續 (cánliú gōngnéng chíxù)
10. Endocrine Cross-Talk — 內分泌系統交互作用 (nèifēnmì xìtǒng jiāohù zuòyòng)
10.1 Immune-Endocrine Interface — 免疫-內分泌介面 (miǎnyì-nèifēnmì jièmiàn)
10.1.1 Cytokines → Endocrine — 細胞因子→內分泌 (xìbāo yīnzǐ → nèifēnmì)
- IL-1 — 白介素-1 (báijièsù-1)
- IL-6 — 白介素-6 (báijièsù-6)
- TNF-α — 腫瘤壞死因子α (zhǒngliú huàisǐ yīnzǐ α)
- IL-2 — 白介素-2 (báijièsù-2)
- Interferon-γ — 干擾素γ (gānrǎosù γ)
10.1.2 Hormones → Immune — 激素→免疫 (jīsù → miǎnyì)
- Cortisol — 皮質醇 (pízhìchún)
- DHEA — 去氫表雄酮 (qùqīng biǎoxióngtóng)
- Oestrogens — 雌激素 (cí jīsù)
- Testosterone — 睪酮 (gāotóng)
- Vitamin D — 維生素D (wéishēngsù D)
- Melatonin — 褪黑素 (tuìhēisù)
- Leptin — 瘦素 (shòusù)
- GH / IGF-1 — 生長激素/胰島素樣生長因子-1 (shēngzhǎng jīsù / yídǎosù yàng shēngzhǎng yīnzǐ-1)
10.2 Neuroendocrine Signalling — 神經內分泌信號 (shénjīng nèifēnmì xìnhào)
10.2.1 Neuropeptides — 神經肽 (shénjīngtài)
- Substance P — P物質 (P wùzhì)
- CGRP — 降鈣素基因相關肽 (jiànggàisù jīyīn xiāngguān tài)
- VIP — 血管活性腸肽 (xuèguǎn huóxìng chángtài)
- NPY — 神經肽Y (shénjīngtài Y)
- Orexin A & B — 食慾素A與B (shíyùsù A yǔ B)
- Galanin — 甘丙肽 (gānbǐngtài)
- PACAP — 垂體腺苷酸環化酶激活多肽 (chuítǐ xiàngānyǎnsuān huánhuà méi jīhuó duōtài)
10.2.2 Reproductive Neuroendocrine Regulators — 生殖神經內分泌調節因子 (shēngzhí shénjīng nèifēnmì tiáojié yīnzǐ)
- Kisspeptin — 親吻肽 (qīnwěntài)
- Neurokinin B — 神經激肽B (shénjīng jītài B)
- Dynorphin — 強啡肽 (qiángfēitài)
10.2.3 Endogenous Opioids & Cannabinoids — 內源性阿片類與大麻素 (nèiyuánxìng āpiànlèi yǔ dàmásù)
- β-Endorphin — β-內啡肽 (β-nèifēitài)
- Enkephalins (Met-, Leu-) — 腦啡肽(甲硫、亮)(nǎofēitài (jiǎliú, liàng))
- Endocannabinoids (AEA, 2-AG) — 內源性大麻素(花生四烯酸乙醇胺、2-花生四烯酸甘油)(nèiyuánxìng dàmásù (huāshēng sìxīsuān yǐchún’àn, 2-huāshēng sìxīsuān gānyóu))